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目錄:愛必信(上海)生物科技有限公司>>抗體>>二抗>> abs131127Rabbit anti-Twist1 Polyclonal Antibody

Rabbit anti-Twist1 Polyclonal Antibody

  • Rabbit anti-Twist1 Polyclonal Antibody
參考價1500
具體成交價以合同協(xié)議為準(zhǔn)

參考價:¥ 1500

具體成交價以合同協(xié)議為準(zhǔn)
  • absin 品牌
  • abs131127 型號
  • 生產(chǎn)商 廠商性質(zhì)
  • 上海市 所在地
規(guī)格

50ug

屬性

分子量:21kD 供貨周期:現(xiàn)貨 規(guī)格:50ug;100ug 貨號:abs131127 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:WB:1:500-1:2000, IHC:1:50-1:200

>
規(guī)格
50ug1500元999ug可售

更新時間:2025-11-03 15:04:22瀏覽次數(shù):1637評價

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分子量 21kD 供貨周期 現(xiàn)貨
規(guī)格 50ug;100ug 貨號 abs131127
應(yīng)用領(lǐng)域 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途 WB:1:500-1:2000, IHC:1:50-1:200
Rabbit anti-Twist1 Polyclonal Antibody Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 th

Rabbit anti-Twist1 Polyclonal Antibody

概述
描述
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.
別名
Twist1抗體;ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; Class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; OTTHUMP00000116043; SCS; TWIST; Twist basic helix loop helix transcription factor 1; Twist family bHLH transcription factor 1; Twist homolog 1 (Drosophila); Twist homolog 1; TWIST homolog of drosophila; Twist related protein 1; Twist-related protein 1; TWIST1; TWST1_HUMAN,Twist1
宿主
Rabbit
特異性
The antibody detects endogenous levels of total Twist1 protein.
反應(yīng)種屬
Human, Mouse, Rat
應(yīng)用
WB:1:500-1:2000, IHC:1:50-1:200, IF/ICC:1:100-1:500, ELISA(peptide):1:20000-1:40000
分子量
Predicted molecular weight: 21kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
免疫原
A synthesized peptide derived from Human TWIST1(Accession Q15672), corresponding to amino acid residues M1-P24.
性能
濃度
1mg/ml
純化方法
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
類型
Polyclonal Antibody
儲存/保存方法
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
存儲溶液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
標(biāo)記
Unlabeled
修飾
Unmodified
靶標(biāo)
背景說明
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
組織特異性
Subset of mesodermal cells.
細(xì)胞定位
Nucleus;
UniProt
Q15672
Rabbit anti-Twist1 Polyclonal Antibody溫馨提示:本產(chǎn)品僅作科研實驗使用,不支持臨床等研究


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